The Chill Pill: The One Drug You Should Be Taking

I review studies almost everyday. Most are on food, exercise, or supplements and how they might better your life. But there’s one topic, far less popular, that’s a constant theme running through many of these, which leads to better results 100% of the time: chilling out.

Today’s post highlights an article from Dan Buettner and NY Times on some of the longest living populations in the world. The main character left the US for his native home on an island in Greece to die when he was diagnosed with terminal cancer nearly four decades ago. The laid back agrarian lifestyle not only cured his cancer but allowed him to out live all of his doctors.

Six months came and went. Moraitis didn’t die. Instead, he reaped his garden and, feeling emboldened, cleaned up the family vineyard as well. Easing himself into the island routine, he woke up when he felt like it, worked in the vineyards until midafternoon, made himself lunch and then took a long nap. In the evenings, he often walked to the local tavern, where he played dominoes past midnight. The years passed. His health continued to improve. He added a couple of rooms to his parents’ home so his children could visit. He built up the vineyard until it produced 400 gallons of wine a year. Today, three and a half decades later, he’s 97 years old — according to an official document he disputes; he says he’s 102 — and cancer-free. He never went through chemotherapy, took drugs or sought therapy of any sort. All he did was move home to Ikaria.

It’s an amazing story that’s less unique that you might think. I can’t recall how many instances I’ve noticed the common theme of improvement in a study is linked more to a lifestyle change than whatever was being studied, especially when that change led to less stress.

Of course we can’t all move to an island. We can, however, chill out. It’s entirely within our scope, no matter what we do and where we live. Remember the Seinfeld (the show about nothing, aka everything) when George becomes the “opposite of every man you’ve ever met” and his casual dismissal of a car cutting him off turns on the woman he’s with? That was more than self-deprecating humor. It was a lesson.

We’ve become a nation of control freaks in the world that can’t be controlled. It’s a no win scenario. We look for distractions to ignore it but these things, like sports, TV, political nonsense et al, make it worse as they too are uncontrollable. We need to focus inward, on our day-to-day lives and what makes them rich, which is not money but our relationship with others around us. "It's not the end of the world," is a cliche we too often ignore. What are we in such a hurry to do, anyway?

In Samos, they care about money. Here, we don’t. For the many religious and cultural holidays, people pool their money and buy food and wine. If there is money left over, they give it to the poor. It’s not a ‘me’ place. It’s an ‘us’ place.”

You don’t need to move to an island to do this. All you need to do is find a way to relax. Exercise and diet, both major elements in the story, are the best place to start because they force your body into a more relaxed and healthy-functioning state. The rest is completely within your control and you can start right now, by reading the article, which sufficed as my daily dose of chill. Now maybe I'll unplug my clocks.

Seeking to learn more about the island’s reputation for long-lived residents, I called on Dr. Ilias Leriadis, one of Ikaria’s few physicians, in 2009. On an outdoor patio at his weekend house, he set a table with Kalamata olives, hummus, heavy Ikarian bread and wine. “People stay up late here,” Leriadis said. “We wake up late and always take naps. I don’t even open my office until 11 a.m. because no one comes before then.” He took a sip of his wine. “Have you noticed that no one wears a watch here? No clock is working correctly. When you invite someone to lunch, they might come at 10 a.m. or 6 p.m. We simply don’t care about the clock here.

stamatis moraitis tending his vineyard and olive grove on ikaria. andrea Frazzetta/LUZphoto for The New York Times

62,000 Bad Things and 6 Good Things

Dr. Mercola can be an alarmist wanker but he spins a plenty of good advice as well. And when I say spin I mean it in a myriad of ways. Two of those involve him trying to sell you stuff and ranting like a spinning top. But I love a good rant so, for today’s entertainment, I present his version of 62,000 bad things and 6 good things.

First, as his article is titled, we’ll look at the bad. Did you know that drugs were 62,000 times more likely to kill you than supplements? Well, it’s true, apparently, though I didn’t dig too deep into how he did the math. I mean, when every single drug ad on TV has a running list of possible side effects, often including death, that barely squeeze into the allotted time slot I don’t think bickering about numbers is necessary. But just in case you didn’t get the memo, our favorite hippy doctor hammers you with plenty of statistics, and enough conspiracy theories to make Robert Ludlum proud.

In striking contrast, drugs are known to cause well over 125,000 deaths per year in the US when taken correctly as prescribed – yet the FDA allows fast-track approvals and countless new additions of poorly tested drugs to the marketplace that must later be withdrawn due to their lethal consequences.

Obviously that statement is a little off the cuff since, well, we still have law enforcement in this county. But it’s worth reading, even with a skeptical eye, because much of what he’s saying makes too much sense not to be at least somewhat true.

He then leaves us with a shiny, happy ending so he can sell us some of his stuff. But, hey, a guy’s got to make a living and his 6-lifestyle recommendations to avoid meds are worth reiterating. I’m not sold they’ll mean that you’ll “never need medication” but they’ll certainly stack the odds in your favor. I’ve presented them here abridged but click anywhere for the full rant. I mean report.

1. Proper Food Choices Generally speaking, you should be looking to focus your diet on whole, unprocessed foods (vegetables, meats, raw dairy, nuts, and so forth) that come from healthy, sustainable, local sources, such as a small organic farm not far from your home....

2. Comprehensive Exercise Program, including High-Intensity Exercise High-intensity interval-type training boosts human growth hormone (HGH) production, which is essential for optimal health, strength and vigor...

3. Stress Reduction and Positive Thinking You cannot be optimally healthy if you avoid addressing the emotional component of your health and longevity, as your emotional state plays a role in nearly every physical disease -- from heart disease and depression, to arthritis and cancer...

4. Proper Sun Exposure to Optimize Vitamin D We have long known that it is best to get your vitamin D from sun exposure, and if at all possible, I strongly urge you to make sure you're getting out in the sun on a daily basis...

5. Take High Quality Animal-Based Omega-3 Fats Animal-based omega-3 found helps fight and prevent heart disease, cancer, depression, Alzheimer's, arthritis, diabetes, hyperactivity and many other diseases...

6. Avoid as Many Chemicals, Toxins, and Pollutants as Possible This includes tossing out your toxic household cleaners, soaps, personal hygiene products, air fresheners, bug sprays, lawn pesticides, and insecticides, just to name a few, and replacing them with non-toxic alternatives...

Bad Medicine

Here's an excerpt from a beautiful eulogy Romney wrote for Beata. I think our old dog, Tuco, might miss her more than anyone. He’s REALLY old, seems out of it a lot, but when we were going to the vet before she died he was totally engaged and has been very clingy (which is exceedingly odd and not a trait natural to “Mr. Bitter”) since she did not come home.

For the past 9 years (minus one) Beata has been my friend, family, and love. She has never judged me for my poor culinary or film choices – or even been mad when I tell her not to bury her bones in the garden (because she always did it anyway). She never wanted anything more than to be loved and not abandoned. She was the cutest, sweetest, most loving little dog. My heart aches that I will never see her wag her body at me again, or get to cuddle on the couch with her while Edwards is on business trips. Edwards and I lost a vital member of our family last night, and Tuco lost his “girlfriend” who brought him back so much “psych”.

Anyway, this is a health blog so let’s get back to business. I didn’t do my homework on the medications she was taking post surgery, and this killed her. I figured—incidentally with the same rationale I used when I hurt my back and didn’t check on that medication—how bad can a couple of weeks of anti-inflammatory meds be? Bad, as it turns out.

What we have is the Vioxx scandal for dogs. The only reason we don’t hear more about it is that it’s for dogs, though it did make the Washington Post in this article:

Vioxx Debate Echoed in Battle Over Dog Drugs

And the medication that kicked it off, Deramaxx, is like candy compared to the one that killed B, Previcox. When I Googled it on the night she died I was shocked that EVERY SINGLE WEB SITE THAT WASN’T TRYING TO SELL IT WAS A WARNING OF ITS DANGERS. The net is littered with stories exactly like ours, of healthy animals seeing a vet for an injury and dying due to complications with the medication. Some of these pages also contain angry letters from vets (or perhaps pharmaceutical PR people but that’s another story) stating that slamming the medication would only serve to hurt other dogs. Well, at least it might hurt the ones that don’t die.

Being more of the scientific type, I dug into studies. Turns out even Merial’s (maker of Previcox) own studies on the drug are highly alarming. Most that they used were done on three day post surgery groups. In these groups many small dogs died (so it shouldn’t be used on dogs under 12lbs) and many had internal bleeding. Then there were some longer 180 days studies. In these many dogs died, almost all had side effects and internal bleeding. That is the POSITIVE research.

Then there are the FDA reports on drug safety. Here we see how Previcox has become safer through the years. In 2005 and 2006 it was killing over 10% of its users. Now it’s down to just over 1%. This is not a typo. How would you feel if every time you popped some ibuprofen there was a 1 in 100 chance that you’d die?

It’s not like we’re trying to cure an aggressive form of cancer where the patient would die without the medication. We’re just reducing some swelling. So why are vets shilling something almost certain to have side effects with a high risk of death? Even more so, why aren’t there at least strong warnings given to the customers? The answer, I suppose, comes right back around to Vioxx, which doctors continued to prescribe as it was killing thousands of people even though there were plenty of safe alternatives. Okay, that’s not an answer. An answer would be speculative so I’ll let you make one up. The only fact we know for certain is that it happened with Vioxx, it’s happening now with Previcox and Deramaxx, and, for those of you who don’t have pets, it’s still happening with other medications that are killing people.

Ironically that last article showed up the night B died. I will deconstruct it later this week. The point today is to warn you against the dangers of NSAIDS for both animals and humans. NEVER TAKE (OR GIVE TO YOUR PET) ANY MEDICATION THAT YOU HAVEN’T RESEARCHED AND ASSESSED THE RISK. Not even for something that seems innocuous, and not even for one day. Those in the medical field may call you alarmist (they often use analogies like “you aren’t qualified to understand the science”) but I call it being informed. And whether or not your information is “faulty” dead is still dead. You don’t need a degree to understand that.

pics: beata and tuco and, what we thought, might be one of HIS last trips to the coffee house where they were fixtures. mr. bitter is not happy. climbing won't be the same knowing b's not watching out for me.

The Anti-Inflammatory Myth

“There is no indication or rationale for the current prophylactic use of NSAIDs by athletes, and such ritual use represents misuse.”

Say what? If you’re like a lot of my friends you might want to re-think your use of vitamin I. NSAIDs might be the most commonly-used “supplement” in the sports world. The latest research indicates this should change. Check out this article from Gretchen Reynolds (who has been on a roll with cutting edge advice lately):

Phys Ed: Does Ibuprofen Help or Hurt During Exercise?

Essentially, a bevy of studies have shown that using anti-inflammatory medication to reduce exercise-induced inflammation and, hence, protect ourselves against injury doesn’t work. As the article states, this is a very common practice (A study of professional Italian soccer players found that 86 percent used anti-inflammatories during the 2002-2003 season).

In the sports world jargon, up may as well be down. Here’s an explanation:

“ Warden and other researchers have found that, in laboratory experiments on animal tissues, NSAIDs actually slowed the healing of injured muscles, tendons, ligament, and bones. “NSAIDs work by inhibiting the production of prostaglandins,”substances that are involved in pain and also in the creation of collagen, Warden says.”

I’ve always tried to limit my NSAID intake to when necessary. All drugs are hard on one human system or another, so there’s always a trade off to consider. This, however, has not meant that I used them sparingly. Like most athletes, I suffer from a lot of aches, pains, and inflammation. However I never took these to mask pain. I took them because I thought keeping inflammation at bay would reduce the odds of injury. Apparently this is false. In a study done at the Western States 100:

Those runners who’d popped over-the-counter ibuprofen pills before and during the race displayed significantly more inflammation and other markers of high immune system response afterward than the runners who hadn’t taken anti-inflammatories.

I guess this puts us right back in the no pain, no gain school of training. Next time things start to hurt a little consider this:

If “you’re taking ibuprofen before every workout, you lessen this training response,” Warden says. Your bones don’t thicken and your tissues don’t strengthen as they should. They may be less able to withstand the next workout. In essence, the pills athletes take to reduce the chances that they’ll feel sore may increase the odds that they’ll wind up injured — and sore.

Now we just need to interpret which is the good pain that we should push through, and which is the bad pain that’s hurting us.

Exercise Versus Paxil

If you're on my blog, this is probably preaching to the choir. It's still funny though.

Exercise Without Exercise

Two drugs could be on the way that would change the world as we know it. I'm not prepared to go into a philosophical discourse on the subject yet. There could be many downsides (and scary sides) to this should it work as advertised, but a primary one could be the loss of sports and competition to the world.

This is a far cry beyond what we now consider sports doping to be. At best, doping creates an advantage over like-trained individuals. In tests with mice, those that exercised while taking GW1516 increased their performance by 77%. This would mean that athletes could actually be made from scratch. What this would do is take away the current explorative nature of our beings to find out just what the limits of the human body are. That is the true nature of sport. While this has been altertered, slightly, with modern doping practices it's now where near where it could be.

I suppose it's possible that we'll roll with this and just accept medical changes as part of sport. But I'm pretty uncomfortable with that thought at the moment.

Here are a couple of articles:

http://www.emaxhealth.com/69/23617.html

http://www.webmd.com/fitness-exercise/news/20080731/exercise-in-a-pill-maybe

Drug Companies Suppress Release of Sicko?

From the wires...

One week before Michael Moore’s hotly debated documentary Sicko was scheduled to open, Mark H. Rachesky, M.D. -- the founder and president of MHR Fund Management LLC -- purchased 33.4 percent (over 40 million shares) of Lions Gate stock.

Lions Gate (along with Weinstein Co.), the company distributing Sicko, had planned to release the film in over 1,600 theaters across the United States in June 2007. However, one week prior to the release (the same week that Rachesky made his purchase), the number was reduced to 400 theaters.

While this could be mere coincidence, some are questioning whether Rachesky’s stock purchase was made for controlling interests in Lions Gate. Typically, for a shareholder to gain major influence on a company, he or she would need to purchase at least 51 percent of the shares.

However, in certain instances an individual can maintain control with just 33.4 percent of shares… which is the exact amount that Rachesky purchased.

Further, Rachesky is involved with a number of health care companies who stand to be impacted by Moore’s provocative film. Rachesky is:

On the Board of Directors of Keryx Biopharmaceuticals, Inc.
An investment broker for NovaDel Pharma, Inc.
The beneficial owner of Medical Nutrition USA, Inc.
The Director of Neose Technologies, Inc., a clinical-stage biopharmaceutical company
An investor in Emisphere Technologies, Inc., another biopharmaceutical company
Sicko examines the financial and medical struggles of Americans to get proper health care, and chronicles the experience of a group of World Trade Center rescue workers who travel to Cuba to get medical care, for free.


The Zetetic August 4, 2007

New Diet Drug

I hope I don't get stuck sitting next to one of these "5 to 6 million" people.

Boxes of Alli, the first FDA-sanctioned diet drug to be sold without a prescription, are selling in huge numbers, despite the fact that the pill comes with the potential for extremely unpleasant and embarrassing side effects.

The manufacturer has predicted that 5 million to 6 million Americans a year will buy the drug.

The GlaxoSmithKline drug, which was introduced to the market several years ago in a prescription-only form called Xenical, blocks the absorption of about 25 percent of consumed fat. That would eliminate about 225 calories from a 3,000 calorie per day diet.

However, the drug can also result in loose stools and gas with an oily discharge. The drug's official website states that, "It's probably a smart idea to wear dark pants, and bring a change of clothes with you to work," if you take the drug.

Los Angeles Times June 15, 2007

Trust Your Local Pharmaceutical Company

I really see no need for comment. More fun from Big Pharma, courtesy of Dr. Jay Rowen, MD.

Inventing a Disease

You've got to admire the chutzpah of the marketers at pharmaceutical giant Glaxo-SmithKline PLC. They've figured out how to increase sales for one of their most popular drugs by more than $300 million a year. All they had to do was invent a disease for it to treat.

The name of the drug is Requip. It works by regulating the brain chemical dopamine, which is responsible for controlling body movements. It's effective enough that it has become the drug of choice for doctors treating patients with Parkinson's disease.

Then someone at Glaxo had an "ah-ha!" moment. There are millions more people who suffer from leg twitches at night than Parkinson's. What if Requip became the drug of choice for them? Only problem was, "leg twitches" isn't a disease. So HMOs and insurance companies won't pay for prescriptions to treat it.

The wizards at Glaxo decided on a three-step campaign to change all that. First, they spent millions of dollars to educate the medical profession about a new disease. But not "leg twitches." No, "restless leg syndrome" sounds much more serious. And "syndrome" is almost the same thing as "disease," isn't it? Glaxo's ads in medical journals started carrying the tagline, "GlaxoSmithKline: A Leader in RLS Research."

Next, Glaxo hired dozens of "sleep-disorder specialists" to go around the country, pitching local doctors about the seriousness of RLS and the wonders Requip could work in treating it. They invited the docs to lavish meals at country clubs and four-star restaurants, with Glaxo picking up the tab. They attended by the hundreds.

Finally, Glaxo spent millions more on TV ads aimed directly at consumers, to tell them that their pain has a name - and a drug to help treat it. Before you could say "gimme some of them pills," Glaxo's sales of Requip increased by more than $300 million a year. As they say, that ain't hay.

But before you rush off to your doctor and ask him to prescribe a bottle or two of Requip for you, here's a suggestion from one of my favorite health writers. Dr. Robert Rowen, editor of Second Opinion newsletter (www.secondopinionnewsletter.com), says if you're bothered by leg twitches at night, chances are you're suffering from a potassium deficiency.

He suggests eating a banana or two before you go to bed. Or get a bottle of potassium supplements from your local health food store. You could solve your problem without spending a fortune … or taking a fancy new drug with who-knows-what side effects.

New Diet Pill

This goes into the Friday dump, since that's pretty much were it belongs:

Diet Pill okay'd by FDA

Funny thing is, you don't even have to read the fine print. Right up front they say it only works with diet and exercise, and if you were eating well and exercising you wouldn't need it. They're also saying it could cost $60 a month. This is equal to a gym membership, payments on a super nice bike, a bushel of fruits and veggies or, hell, a round of drinks for you friends as a reward for all those improvements in diet and exercise you've been making since you decided to just do that part of the equation and skip to drug.

Also, if this supplement sounds interesting to you, consider trying chitosan first. It's cheaper and, more or less, does the same thing with less gastric stress. I've seen it be effective in certain circumstances but, in general, it's no major player in ones fitness transformation.

Drugs or Food?

Found this on the wires today:

Food Affects Some Like Drugs

Interesting in the wake up my feature article last week:

Food, Drugs, and Supplements: What's the Difference?

Part of my piece discusses which aided/hindered the person more, Bonds' nefarious drug use or The Babe's imfamous "diet".

While I'd like to file this under the "duh files", I can't. Our society seems to become more and more disconnected to their own bodies. We really need to change our education system. This should be basic knowledge for everyone, not some elective class that most people skip. It's just about the most fundamental thing we should learn--how our body works and how to take care of it. But I'll refrain from ranting today. Just read this stuff and see if you agree.